Researchers have worked for years to provide solutions that will help humans live longer and healthier lives. Jason Hope is an entrepreneur, futurist, philanthropist, and investor with innovative ideas that could move this research forward.
Hope is fueled by a passion for technology and giving back to his community. He grew up in Tempe and holds a degree in finance as well as an MBA from W.P. Carey School of Business. He has been involved with several philanthropic and business initiatives and has a keen interest in politics in relation to the business field.
Science is a major interest for Jason Hope. He is a long-time supporter of the SENS (Strategies for Engineered Negligible Senescence) Organization. The organization’s mission is to implement medical therapies that will postpone age-related illnesses.
Hope is dedicated to staying updated on groundbreaking research and shares his thoughts and ideas through various platforms including speaking events, media outlets, and more. He is fascinated with stem cell therapy research and other longevity therapies.
This article will take a look at some of the innovative ideas Jason Hope has backed and introduced regarding longevity and anti-aging research.
Eliminating Senescent Cells
Cellular senescence is commonly linked to the suppression of tumors and can be beneficial in fighting cancer. Both age-related diseases and beneficial processes have been linked to senescence cessation in recent years.
Hope puts forth the theory that the link between cell senescence and age-related disease could be eliminated with a twice a week injection of AP20187 that will remove senescent cells. Animal studies have shown these injections have been effective in delaying disease while increasing quality of life. Follow up studies are being conducted on humans as well.
Senescence is a natural process that occurs in cells to prevent damaged cells from growing. It kills the cells, and the immune system disposes of them. This process helps with tissue repair and reduces the risk of cancer.
The problem is, as we get older, our immune system loses its ability to clear these damaged cells. The cells accumulate resulting in inflammation and a reduced ability to substitute for cell loss. Therefore, senescence stops protecting us and instead, works to speed up the aging process.
Jason Hope believes these injections will reduce senescence as we age helping future generations to live longer.
Jason Hope Working with DNA
NAD+ is a chemical that protects DNA, but it deteriorates as we get older. Hope believes that the NMN chemical (nicotinamide mononucleotide) can substitute for NAD+ working to revamp DNA and protect humans from age-related diseases.
NMN converts to NAD+ in our bodies. In animal studies, older mice given the chemical were shown to have cell constructions that were indistinguishable from that of younger mice. Studies have since been conducted that show the administration of NMN to have similar and safe effects in humans.
In the past, scientist Shinya Yamanaka conducted studies regarding the resetting of adult cells to a younger state. While Yamanaka did not find success with his ventures, his attempts inspired scientists to work with Yamanaka factors to achieve a similar goal.
More recent studies show the administration of these factors to be effective in reducing inflammation and producing younger cells in arthritic joints. Hope backs these findings and feels further research can lead to significant breakthroughs.
Hope backs the theory that the key to anti-aging may be as simple as taking the right medications.
In 2019, scientists combined the medications trametinib, rapamycin, and lithium. When used on fruit flies, the cocktail was shown to extend lifespan by 48%
That same year, the second group of scientists combined the diabetes drug metformin, the human growth hormone rHGH, and DHEA steroids and experimented on humans. In the course of the study, human subjects lost 2.5 years of aging.
Jason Hope feels continued scientific efforts will work to produce medications that can further slow the aging process.
Jason Hope on Anti-Aging Surgery
We have already seen how surgery can reverse aging. Replacing a knee, a hip, or a major organ, for instance, can give a patient a new lease on life.
Now researchers are studying surgery procedures that repair tissues and organs taking out aging agents and returning patients to a more youthful state. Although Hope admits much research will be needed before surgical methods are successful in reversing aging, he feels this is a subject worth exploring.
Jason Hope’s Views on Stem Cell Research
Jason Hope is a great believer in stem cell research. He feels regenerative stem cell therapy can be key in extending human longevity.
Stem cell therapy repairs damaged cells in the body. Regenerative stem cell therapy uses stem cells to speed up the repair process in damaged cells.
Stem cells exist throughout the body, primarily in placental tissue, adipose tissue, bone marrow, and umbilical cord tissue. They are self-replicating and can multiply to create identical forms of themselves. They can be administered into the body via injection, IV, or intrathecal means.
Once administered, stem cells work to reduce inflammation and boost the immune system both of which provide anti-aging effects. They have also been effective in treating auto-immune diseases such as MS, Lupus, Parkinson’s Alzheimer’s, and orthopedic issues.
There are three different types of regenerative stem cell therapy. The first is rejuvenation which aids the body with self-healing. Replacement requires using cells of a compatible donor to replace damaged tissues and organs. Regeneration involves delivering specific stem cells to certain tissues and organs to improve their functionality.
Hope believes that this regenerative stem cell therapy is the ideal healing solution for damaged tissues and an effective anti-aging solution.
Spanners are people who make efforts to expand their lives. They may do something as simple as eating right and exercise each day to increase the quality of life and longevity or they may actively seek out new research and technology taking innovative approaches to find the fountain of youth.
Transhumanism is the integration of technology and biology. Many spanners believe the body is inherently limited and that considerable longevity is only possible with scientific methods that go beyond human capabilities.
Biohackers are a more extreme subset of the transhumanism movement. They integrate technology to obtain more immediate goals. For instance, they might turn to tech to help them lose weight or even get a better quality of sleep.
While Hope admits that some spanning methods can be risky and may not produce a payoff, he feels we all have a lesson to learn from those that are making the effort. He believes that the proactive actions spanners are taking will pay off long term.
Jason Hope is an innovative spirit with an eye on the future. The effort he is putting in now can help people live longer lives for generations to come. We can only wait and see how his theories and the research he backs will change our future for the better.
About Jason Hope
Jason Hope is an entrepreneur, futurist, philanthropist, and investor with innovative ideas in anti-aging development. His efforts are fueled by a passion for technology and a need to give back. He uses a variety of platforms and media outlets to introduce information that can increase longevity and quality of life for future generations.